Unlocking the Potential of Oxadiazole Compounds: A Comprehensive Review of their Anticancer Applications

Abstract

This review highlights the promising role of oxadiazole compounds in the field of anticancer research. Through an extensive exploration of their diverse chemical structures and mechanisms of action, it is evident that oxadiazoles possess significant potential as anticancer agents. Their ability to target various signaling pathways involved in cancer progression, combined with favorable pharmacokinetic properties and low toxicity profiles, positions them as attractive candidates for further development. However, despite the encouraging preclinical and early clinical data, challenges remain in optimizing the efficacy and safety of oxadiazole-based therapeutics. Future research efforts should focus on enhancing their selectivity towards cancer cells, improving their bioavailability, and elucidating their precise molecular targets. Additionally, the development of innovative drug delivery systems could facilitate the targeted delivery of oxadiazole compounds to tumor sites while minimizing off-target effects.

Keywords: oxadiazoles, pharmacokinetic properties, anticancer, cancer cells, bioavailability